GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and a primary member of the growth hormone secretagogue family. It functions as a potent agonist of the ghrelin receptor (GHS-R1a), stimulating robust growth hormone (GH) release from the pituitary gland. This peptide serves as a critical research tool for investigating the GH axis, ghrelin signaling, and metabolic regulation.
- •Potent GH secretion via ghrelin receptor activation.
- •Strong orexigenic properties for feeding behavior research.
- •Dose-dependent GH release supporting flexible protocols.
- •Minimal observed impact on cortisol levels in research models.
- •Stimulates downstream IGF-1 production for anabolic studies.
- •Valuable for investigating cachexia and wasting conditions.
- •Supports research into muscle mass and body composition changes.
GHRP-6 primarily acts as an agonist for the Growth Hormone Secretagogue Receptor (GHS-R1a), which is densely expressed on pituitary somatotrophs and in hypothalamic nuclei. Binding to GHS-R1a triggers intracellular signaling cascades, involving calcium mobilization and Protein Kinase C activation, culminating in the pulsatile release of stored Growth Hormone. This action is synergistic with endogenous Growth Hormone-Releasing Hormone (GHRH), amplifying the overall GH response. The peptide also exerts significant effects on energy balance by activating GHS-R1a receptors within the hypothalamic arcuate nucleus. This activation stimulates orexigenic neurons (NPY/AgRP), leading to pronounced appetite stimulation. The subsequent release of GH initiates the GH/IGF-1 axis, promoting hepatic and peripheral Insulin-like Growth Factor-1 production, which drives downstream anabolic and metabolic effects.
GHRP-6 is extensively utilized in studies focusing on the dynamics of growth hormone secretion and pulsatile GH release patterns. Its dual functionality makes it indispensable for investigations into ghrelin receptor signaling, appetite regulation, and energy homeostasis, particularly concerning the relationship between GH and feeding behavior. Key translational research areas include modeling cachexia and wasting syndromes, examining metabolic regulation, and studying interventions for age-related GH decline. Furthermore, GHRP-6 supports research into body composition, muscle mass maintenance, and is employed in comparative studies alongside other GHS analogs and GHRH peptides.
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Long-acting growth hormone-releasing hormone analog with extended half-life
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.